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Tag Archives: acid base balance

Compensation of Acid-base Disorders

Acid Base Balance

Compensatory mechanisms restore pH towards normal by altering pCO2 and HCO3-. Compensation of metabolic acidosis The lowered pH acts on peripheral chemoreceptors to stimulate the ventilation. Respiratory rate increases and pCO2 falls: ↓CO2 + H2O  ←  H2CO3  ←  H+ + HCO3- [H+] therefore falls, as does [HCO3-]. There is also increased reabsorption of HCO3- and increased excretion of H+from the kidneys but this is …

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Respiratory Acidosis

Respiratory Acidosis FCEM Prep

In respiratory acidosis there is raised pCO2 as the respiratory system is unable to remove enough CO2 from the body. The reaction is driven to the right, causing a rise in [H+], (i.e. a fall in pH). This inability to remove CO2 is often coupled with a failure to keep up with O2 demand. This is respiratory failure. There are two types of respiratory failure …

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Metabolic Acidosis

Metabolic Acidosis - FCEM Prep

CO2 + H2O ↔ H2CO3 ↔ H+ + HCO3-  ‘In metabolic acidosis, there is either additional acid (H+) production on the right side of the equation, or direct loss of bicarbonate which drives the equation to the right, increasing H+ and lowering pH.’ The consequent reduction in pH stimulates the respiratory centre to increase ventilation and lower pCO2. This in turn drives the reaction …

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